IL24 and infection: For example, studies performed by Yacoub and Park et al. demonstrated the accumulation of ceramide/dihydroceramide, elevation of Ca2+, production of reactive oxygen species (ROS) (peaking at 12 h post-infection), and the subsequent activation of autophagy in glioma cells 12 h after infection with a recombinant IL-24-armed adenovirus [19].