Remarkably, IHC induced a significant increase in the levels of mitochondrial fusion protein Mnf-2 (Figure 5C) and a significant decrease in the active form of DRP1 (Figure 5D) and Fis1 (Figure 5E) in the brain of 3×Tg-AD mice, suggesting a shift of mitochondrial network dynamics towards mitochondrial fusion. Here, FIS1 is linked to Alzheimer disease.