KIF5B and Alzheimer disease: Notably, IHC was able to significantly increase both dynein and KIF-5B and decrease syntaphilin protein levels in the brain cortex of 3×Tg-AD mice (Figure 8A–C) suggesting that IHC enhances the bidirectional transport of mitochondria, favoring the distribution of new mitochondria to the synaptic terminal and mitophagy.