Specifically, immunohistochemistry with 23 cases of colorectal adenoma and 102 cases of primary colorectal carcinoma as well their corresponding metastases (44 lymph nodes, 21 peritoneal deposits, and 16 liver metastases) showed that normal tissues had a negative or weak c-MET expression, whereas c-MET was highly overexpressed in adenomas and primary CRC. This evidence concerns the gene MET and adenoma.