To complicate things even more, a 2018 study reported that σ2/TMEM97 forms a trimeric complex with PGRMC1 and the low-density lipoprotein receptor (LDLR), which is responsible for the rapid internalization of the low-density lipoprotein (LDL) in HeLa cells, a human cervical cancer cell line [8]. Here, LDLR is linked to cervical carcinoma.