In lung cancer cells regulation of the β-catenin/ lymphoid enhancer-binding factor-1 (LEF-1) binding (a major signaling event in EMT), is linked to FUT8 upregulation and disease progression, however in breast cancer cell studies suggest that TGF-β mediated upregulation of FUT8 is independent of β-catenin/LEF-1 [30,49]. This evidence concerns the gene LEF1 and breast carcinoma.