TH and colorectal carcinoma: By performing immunohistochemistry for tyrosine hydroxylase (TH) and vesicular acetylcholine transferase (VAchT) on CRC tissue, Zhou et al. mainly detected sympathetic (TH+) fibers in early phases of CRC, indicating good prognosis, while parasympathetic (VAchT+) innervation was observed in later stages and indicated poor prognoses [73].