TLR4 and silicosis: Notably, the expression of myeloid differentiation factor 88 (MyD88) and toll-like receptor adaptor molecule 1 (TLRAM1) elevate in AMs of humans treated with LPS, indicating that LPS-regulated autophagy may be dependent on TLR4-MyD88 or TLR4-TLRAM1 signaling pathway in human silicosis [50].