IGF1 and Axenfeld-Rieger syndrome: Likewise, declined NO levels in decedents of both CD2F1 and C3H/HeN mouse strains is similar to our previous findings in minipigs models of ARS where decedent radioresistant and radiosensitive minipigs strains manifested declining NO in the their sera that was accompanied with cardiac IGF-1 signaling impairment and enhanced oxidative stress [13,16].