HMOX1 and cancer: So, the increment of BV in plasma of LB and HER2 cancer patients would suggest its implication in signaling and gene expression related to cell growth and cancer progression either by its increased plasma concentration, an up-regulation of the heme oxygenase-1 (HO-1) or a dysregulation of its catabolic enzyme biliverdin reductase (BLVR-A or BLVR-B) [56,57,58].