A fifth study, performed by Mahlakõiv et al. [52], suggests, using a murine reovirus infection model, that there is a compartmentalized IFN system in the gut mucosa with the epithelial cells responding predominantly to the IFNλs, whereas the remainder of the tissue relies on the type I IFNs in the defense against viruses. Here, IFNA1 is linked to Reoviridae infectious disease.