Specifically, these mutations are located on five tumor suppressors (<i>SDHA</i>, <i>RB1CC1</i>, <i>PTCH1</i>, <i>DMBT1</i>, <i>BCR</i>) and eight proto-oncogenes (<i>MERTK</i>, <i>CSF1R</i>, <i>MYB</i>, <i>ROS1</i>, <i>PCM1</i>, <i>FGFR2</i>, <i>MYH11</i>, <i>BRCC3</i>) and have an allele frequency lower than 0.01 in the Genome Aggregation Database (GnomAD). The gene discussed is CSF1R; the disease is neoplasm.