STAT3-mediated activation of several microRNA and both STAT3 and NPM-ALK contributed to microRNA epigenetic silencing in ALK(+) ALCL human cell lines and primary biopsies by up-regulating and recruiting DNA methyltransferase 1 (DNMT1) to miRNAs promoters [43,58]. This evidence concerns the gene NPM1 and anaplastic large cell lymphoma.