INS and type 2 diabetes mellitus: In terms of treatment, the conventional treatments for T2DM are insulin therapy and oral hypoglycemic medications.[3] Meanwhile regular exercise and a well-controlled diet are essential for the management of type 2 diabetes.[5] However, existing medication therapies can cause gastrointestinal side effects such as hypoglycemia, flatulence and diarrhea, as well as adverse reactions such as cardiovascular diseases, which will seriously affect the quality of life of patients.[6]