The investigation of the frequency of efficient and quiescent cTfh cells in atherosclerosis indicated an increase in the frequency of efficient (CD4+CXCR5+ CD45RA-CCR7loPD-1hi) cTfh cells in individuals with high stenosis, accompanied by a decrease in the quiescent (CD4+CXCR5+CD45RA-CCR7hiPD-1lo) cTfh cells. Here, CD4 is linked to atherosclerosis.