To identify conditions in which deficiency of HILPDA may be expected to have a larger effect, we screened mouse liver transcriptome data for upregulation of Hilpda. Interestingly, hepatic Hilpda mRNA levels were increased during NASH caused by feeding mice a methionine- and choline-deficient diet (Figure 2A, based on GSE35961). Here, HILPDA is linked to metabolic dysfunction-associated steatohepatitis.