Histone deacetylases have beenshown to downregulate the expression of von Hippel–Lindau (VHL) and p53, butpromote an increase in hypoxia-inducible factor-1αand vascular endothelial growth factor (VEGF), thereby stimulating angiogenesisby the suppression of hypoxia-responsive tumour suppressor genes [72,73]. Here, VHL is linked to neoplasm.