This insulation is lost as a result of thereduced binding of CTCF, facilitating aberrant interactions between promiscuousenhancers and genes as a result of the altered chromosomal topology caused byepigenetic dysregulation [57].In this context, Platelet-derived growth factor receptorA (PDGFRA), a predominant oncogeneamong gliomas [58] is activatedas a consequence of the epigenetic dysregulation-led decrease in CTCFinsulation, with a potent promiscuous enhancer driving constitutive PDGFRA expression, driving sustained proliferation ingliomas [57]. This evidence concerns the gene PDGFRA and central nervous system cancer.