TAT and HIV-1 infection: These data again validate the ability of kinome analysis in conjunction with MetaCore network analysis software to accurately detect and describe experimental conditions (IL-2 signaling) and phenotypes (TCR signaling) and should provide an efficient tool to guide target identification by providing the ability to distinguish between HIV-1 infection induced changes that are shared by primary and immortalized T cells, and changes that are found in latently HIV-1 infected T cell lines, but tat are not present in primary T cells.