There are reports of intra-host KSHV variability in certain KSHV-endemic populations [39], in children [45], in iatrogenic settings [41–43] and in blood of AIDS-KS patients [44], but these findings were arrived at by Sanger sequencing of PCR amplicon clones of hypervariable regions in K1 or other genes. This evidence concerns the gene KRT1 and Kaposi's sarcoma.