TNFRSF10A and rheumatoid arthritis: While the DR1 and DR4 immunodominant determinant of CII is unaffected by citrullination (it does not contain Arg), these results indicate that citrullination of other Arg residues in CII does not appear to generate novel T cell determinants that exacerbate the pathogenesis in this HLA-DR mouse model of RA.