Specially, GESA analysis in the top 5 of the most significant differences has shown that multiple cancer-related and immune-related gene sets were enriched in the low-CKMT1B group, including notch signaling pathway, antigen processing and presentation, JAK STAT signaling pathway, cytokine metabolic process, interleukin 8 biosynthetic process, positive regulation of chemokine production and so on. The gene discussed is CXCL8; the disease is cancer.