This cellular interaction may also be mediated by chemokine receptors such as Duffy antigen receptor for chemokines (DARC)/ atypical chemokine receptor 1 (ACKR1) towards activation of the tumor-specific immune response by chemo-attraction of leukocytes to inflammatory sites and influencing tumor growth and metastasis [32, 33]. The gene discussed is ACKR1; the disease is neoplasm.