Microsatellite instability-high (MSI-H) CRC, a cancer characterized by the absence of one or two mismatch repair (MMR) proteins such as MSH2, PMS2, MLH1, and MSH6 have been reported to be immunogenic with robust lymphocytic infiltrate due to increased mutational signatures [34] and this may be more frequent in CRC with mucinous histology. This evidence concerns the gene MSH6 and colorectal carcinoma.