However, there was a significant decrease in expression of Bcl-2 in normal colorectal section compared with sections from the untreated CRC rat (p = 0.0056), 25 mg/kg aspirin treated sections (p = 0.0101), aspirin plus FOLFOX sequential-treated sections (p = 0.0034) and aspirin plus FOLFOX concurrent-treated sections (p = 0.007). This evidence concerns the gene BCL2 and colorectal carcinoma.