ANXA5 and colorectal carcinoma: There is significant increase in expression of Annexin V in CRC-bearing rats untreated (Fig 7B, p = 0.0002), aspirin plus FOLFOX sequential (Fig 7D; p = 0.0001) and concurrent (Fig 7E; p = 0.0034) treatments, and folinic acid treated rats (Fig 7F; p = 0.0034) compared with sections from non CRC-bearing rats (Fig 7A).