In this study, we used a systemic approach to elucidate the expression pattern and prognostic significance of Pro and Anti-BIRC7/Livin, Bcl-2, p53, Annexin V, PD-L1 and DARC, and DNA MMR proteins MSH2 and PMS2 in human CRC cells pre- and post-FOLFOX treatments from patients at a West African health institution (Ahmadu Bello University Teaching Hospital) in Zaria Nigeria. The gene discussed is BCL2; the disease is colorectal carcinoma.