Quantitative analysis of PD-L1 showed no significant difference in expression of PD-L1 when comparing normal colon and rectum with CRC- sections untreated (p = 0.0909), treated with 25 mg/kg aspirin (p = 0.8214), aspirin plus FOLFOX concurrent (p = 0.9360) and folinic acid (p = 0.5912) see Fig 9G. Here, CD274 is linked to colorectal carcinoma.