TP53 and colorectal carcinoma: Results from the in vivo study in rats, showed positive expression of p53 and Bcl-2 in sections from non CRC-bearing rats (Fig 7A), and also untreated CRC-bearing rats (Fig 7B), treated with 25 mg/kg aspirin (Fig 7C), aspirin plus FOLFOX sequential (Fig 7D) and concurrent (Fig 7E) treatments, and folinic acid treated rats (Fig 7F).