On the other hand, anti-TNFα and anti-IL-6 cannabis extracts that are generally regarded as safe (GRAS) modalities can be a useful addition to the current anti-inflammatory regimens to treat COVID-19, as well as various rheumatological diseases and conditions such as rheumatoid arthritis (RA), psoriasis and psoriatic arthritis, osteoarthritis, fibromyalgia, and others. The gene discussed is TNF; the disease is osteoarthritis.