We found that extracts # 4, #8, #14 significantly down-regulated cytokine-cytokine receptor interaction pathway, rheumatoid arthritis pathway, chemokine signalling, Toll-like receptor signalling, JAK-STAT signalling and other pathways involved in inflammation, immunity and autoimmunity, as well as tissue remodeling and fibrosis. Here, SOAT1 is linked to rheumatoid arthritis.