In positive early infection group (n=44; 25 males and 19 females; mean age 67.3 years ± 16.6 years), 2 patients (4.54%) were positive to IgG/IgM aCL or IgG/IgM aβ2GP1: one with IgG aCL = 27.9 CU; one with IgM aCL = 34.3 CU and IgM aβ2GP1 = 31.5 CU. The gene discussed is CD40LG; the disease is infection.