SORL1 and Alzheimer disease: A study that used the Exome Aggregation Consortium (ExAC) database (containing genetic variation of 60,706 human samples [66]) classified the pathogenicity of SORL1 variants and found that pathogenic SORL1 variants can increase AD risk by 12-fold as well as cause an earlier age of onset (58.6 ± 5.2 years) for SORL1 carriers [67].