MAPT and Alzheimer disease: The neuropathology of AD brains is characterized by extracellular accumulation of amyloid plaques, consisting of Aβ40 and Aβ42 peptides generated by the cleavage of APP, and intra-neuronal deposition of neurofibrillary tangles (NTF) composed of hyperphosphorylated tau protein (p-tau) [17].