In colorectal cancer, CBX4 can interact with histone deacetylase 3 (HDAC3) to maintain recruited HDAC3 to the Runx2 promoter, which maintains a deacetylated histone H3K27 state to inhibit Runx2 expression, consequently repressing tumor metastasis [48]. This evidence concerns the gene HDAC3 and colorectal cancer.