F3 and Hyperglycemia: Hyperglycemia mediates the transcription of coagulation factors such as tissue factor, Factors VII and VIII, induces direct platelet activation, and exposes coagulation factors through the disruption of the endothelial glycocalyx layer (Boden et al., 2007; Ceriello, 1993; Ceriello et al., 1988; Lemkes et al., 2010; Rao et al., 1999).