Randomized control trials evaluating the effects of insulin on the incidence of chronic heart failure in patients with diabetes, failed to show any benefits of its administration in lowering the hospitalization rates for heart failure (Fitchett David et al., 2017; Gilbert & Krum, 2015; Pocock et al., 2006; The ORIGIN Trial Investigators, 2012). The gene discussed is INS; the disease is diabetes mellitus.