NPPB and cardiac hypertrophy: It is also interesting to observe that an increase in BNP concentration leads to vasodilatation and reducing cardiac hypertrophy (Scharhag et al., 2006) by inhibition of the sympathetic nerves (D'Souza & Baxter, 2003), thus resulting in the protection of cardiac myocytes as presented in studies on animal and cell models (Filippatos et al., 2001).