Although literature on BAC connectivity is sparse, LS is identified as one of the inputs to the BAC (Swanson et al., 2016) and the medial habenula is one of the reported target region, with implication in the control of anxiety and fear responses (Yamaguchi et al., 2013), the connectivity and function of this glutamatergic-PACAP nucleus is largely elusive. The gene discussed is ADCYAP1; the disease is Anxiety.