Adcyap1r1 was strongly expressed in SCH (Figure 6C and Figure 7), which projects in turn to several Adcyap1r1-expressing regions, which control brain state (sleep-wake cycle), such as midbrain behavioral state related structures (MBSR: pendunculopontine, midbrain raphe nuclei, all Adcyap1-expressing) and pons behavioral state related (PBSR: locus coeruleus, superior central nucleus of raphe, pontine reticular nucleus, all Adcyap1-expressing) (Figure 1A–F). The gene discussed is ADCYAP1R1; the disease is spindle cell hemangioma.