Similar to the results shown in human tissue specimens, elastic fibers (black) in the aortic tissue of mice with AMD disintegrated and fractured, the collagen deposition (red) increased, and the F‐actin content and p‐MLC expression were significantly reduced and without a difference in CD68 expression (Figures 4G‐4J, Figures 5A‐3C). Here, MLC1 is linked to age-related macular degeneration.