Furthermore, transferrin receptor 1 knockout (TFR1−/−) mice were used to study the effects of iron deficiency (ID) on aortic development, to observe the effects of different iron metabolism status on the formation of AMD in mice, and to explore the cytoskeleton of vascular smooth muscle cells (VSMCs) under different iron metabolism. The gene discussed is TFRC; the disease is age-related macular degeneration.