Promoting metastasis via activating NF‐κB/SOX4 signaling; promoting cancer cell survival mediated by TNF‐αvia NF‐κB signaling; promoting metastasis and chemoresistance through myeloid cell‐derived S100A8/9; stimulating migration and invasion via activation of the ERK/MMP2/9 signaling. The gene discussed is S100A8; the disease is cancer.