EPAS1 and nonpapillary renal cell carcinoma: At the same time, it is the first time to clarify the regulatory relationship between the most important carcinogen HIF2a in ccRCC and the new concept tumor “slimming,” in which HIF2a decreases the NNT level through miR‐455‐5 p that suppresses tumor cell “slimming,” resulting in the progression of ccRCC.