PRMT5 in association with BRG1‐ and hBRM‐based SWI/SNF chromatin remodelling complexes induces H3R8 and H4R3 arginine symmetric methylation of promoter histones, which in turn leads to transcriptional repression of target tumour suppressor genes such as Suppressor of Tumorigenicity 7 (ST7) and Nonmetastatic 23 (NM23).20 The gene discussed is PRMT5; the disease is neoplasm.