In light of our recent work, which showed that PRMT5 epigenetically represses transcription of WNT/β‐CATENIN antagonists AXIN1, AXIN2 and WIF1 by directly binding to their promoter region and inducing H3R8 and H4R3 symmetric methylation,37 we wanted to verify whether PRMT5 is involved in transcriptional repression of WNT/β‐CATENIN antagonists, DKK1 and DKK3 in breast cancer cells. This evidence concerns the gene WIF1 and breast cancer.