DKK1 and breast cancer: Moreover, PRMT5 inhibition either alone or in combination with Trichostatin A (TSA) and 5‐Azacytidine (5‐Aza) led to transcriptional derepression of DKK1 and DKK3, and decreased expression of WNT/β‐CATENIN target genes, CYCLIN D1 and SURVIVIN. These changes were also accompanied by reduced proliferation, migration, and invasion and enhanced cell death of breast cancer cells.