Moreover, PRMT5 inhibition either alone or in combination with Trichostatin A (TSA) and 5‐Azacytidine (5‐Aza) led to transcriptional derepression of DKK1 and DKK3, and decreased expression of WNT/β‐CATENIN target genes, CYCLIN D1 and SURVIVIN. These changes were also accompanied by reduced proliferation, migration, and invasion and enhanced cell death of breast cancer cells. Here, DKK3 is linked to breast carcinoma.