B cells promote chemotaxis and migration of neutrophils to the site of tissue inflammation and aggravate inflammatory injury in the peripheral blood of patients with CD, followed by high expression of Toll-like receptor 2 (TLR2) and IL-8 on the surface of B cells, indicating that the immune activity of B cells was enhanced during IBD morbidity [30]. The gene discussed is TLR2; the disease is inflammatory bowel disease.