Once again, the mechanism by which CD248 exerts its effects is not clear, however it is clear that genetic deletion is protective in these settings, with CD248 knockout mice showing reduced atherosclerosis (Fig. S1 and Hasanov et al. 2017), reduced weight gain and diabetes (as measured by glucose tolerance tests) on a high fat diet (Petrus et al. 2019). The gene discussed is CD248; the disease is diabetes mellitus.