DCT and melanoma: Then, we showed that adenovirus-forced MITF expression led to an increase in FBXO32 protein expression in both 501MEL and A375 melanoma cell lines (Fig. 2B), while MITF silencing decreased the expression of FBOX32 and DCT, a known transcriptional target of MITF in MeWo and 501Mel cell lines (Fig. 2C).