Moreover, we demonstrated that GPI-m36.4 could efficiently render human CD4+ T cells (CEMss-CCR5) nonpermissive to both CCR5- and CXCR4-tropic HIV-1 isolates and produced a robust survival advantage in transduced cells compared to unmodified cells during HIV-1 infection. This evidence concerns the gene CXCR4 and HIV-1 infection.