GPI and HIV-1 infection: We verified that both GPI-m36.4 and GPI-FluIgG03 were efficiently expressed within the plasma membrane lipid raft sites of transduced TZM-bl cells without interfering with the expression of HIV receptors; however, GPI-m36.4 but not GPI-FluIgG03 specifically rendered target cells highly resistant to divergent HIV-1 infections, viral Env-mediated cell–cell fusion, and cell-associated virion-mediated cell–cell transmission.