As shown in Supplementary Fig. S2, Atg5f⁄f;Vav mice at 7 weeks of age showed severe haematopoietic dysfunctions such as severe anaemia and leukocytopenia associated with an abnormality in balance of peripheral cell components, such as increased ratios of myeloid/B cells, compared with control (Atg5w/w;Vav) mice (Fig. 5a,b). Here, VAV1 is linked to anemia (phenotype).