For example, PMA increases the level of p-AktSer473 in breast cancer cells and mast cells via PKCδ activation and interaction with PKCβ, respectively30,31, but PMA attenuates Akt activity in endometrial cancer cells and mouse keratinocytes via PKCα, and PKCδ and PKCε32,33. Here, AKT1 is linked to endometrial cancer.