SNCA and Parkinson disease: The model should include the standard molecular infrastructure like ion channels, active pumps, ion exchangers, dopamine (DA) turnover processes, energy metabolism pathways, and calcium buffering mechanisms and be able to simulate a rich vein of PD-related molecular processes such as alpha-synuclein aggregation, Lewy body formation, reactive oxygen species (ROS) production, levodopa (L-DOPA) uptake, and apoptotic pathways.