HAVCR2 and neoplasm: The CD8-positive tumour-infiltrating dCAR T cells showed a mild but not significant increase in PD1 + TIM3 + expression from day 7 to day 14, but CD8 + PD1 + TIM3 + expression was strongly upregulated in the tumour-infiltrating CAR T cells from day 7 to day 14 and higher than that in the dCAR T cells on day 14 (Fig. 9f).