Using a combination of western blotting, confocal microscopy, and RNA microarray, we have established that CALCRL, its three co-receptors RAMP1, RAMP2 and RAMP3, as well as ADM (but not CGRP, another putative CALCRL ligand) are expressed in all the tested AML cell lines and primary AML samples (Fig. S1m–r). Here, RAMP3 is linked to acute myeloid leukemia.