However, the ipsilateral hindpaw of mice overexpressing POMC or those overexpressing POMC-MOR combination, demonstrated amelioration in mechanical hypersensitivity upto 1.4 g force (Fig. 6d and Supplementary Table T6) suggesting a modulation of diabetes-associated mechanical allodynia in female (Fig. 6) and male (Fig. S11) mice. This evidence concerns the gene POMC and diabetes mellitus.