In addition, knockdown of KDM4C induced the apoptosis of glioblastoma cells, as demonstrated by the increase in annexin V/PI-positive cells and upregulation of cleaved caspase-3 and cleaved poly(ADP ribose) polymerase (PARP) (Fig. 2B, C, and Fig. S9). This evidence concerns the gene ANXA5 and glioblastoma.