Furthermore, other genes that play important roles in the pathophysiology of MM (such as the cytokines IL6 and OSM) and associated MBD (secreted factors such as RANKL, SFRP2, IL7, CHSY1, COL4A1, and the transcriptional repressor GFI1) were also found to alter their DNA methylation levels (Fig. 1E and Supplementary Fig. 1H). This evidence concerns the gene SFRP2 and Miyoshi myopathy.