ICAM1 and hepatocellular carcinoma: To further explore the role of miR-6852-3p/ICAM-1 axis in the NK cytotoxicity toward HCC mediated by hsa_circ_0007456, we transfected the miR-6852-3p mimic into the hsa_circ_0007456-overexpressing SMMC-7721 and QGY-7703 cells, and examined the their susceptibility to NK cells through the calcein release assay (Fig. 7A, B) and conjugation assay (Fig. 7C, D).