Interestingly, six hours following the intranasal administration of nanoparticles coated with SARS-CoV-2 S-derived CendR peptides to anesthetized adult mice, Cantuti-Castelvetri et al. noted a significant uptake of these, not only in the olfactory epithelium which expresses NRP1, but also into the blood vessels and neurons of the cortex.2 The latter further suggests that the broader NRP1 expression in the olfactory epithelium and the human brain, including olfactory-related regions, may also have implications for the manifestations of COVID-19.5 Here, NRP1 is linked to COVID-19.