BRD2 also drives LPS-stimulated neuroinflammation and alveolar inflammation.40,46 Apart from LPS, listeriolysin-O, a hemolysin produced by the bacterium Listeria monocytogenes, increases BRD4 expression in Kupffer cells, which may induce liver injury by promoting necroptosis, inflammation, and mitochondrial dysfunction.136 Whether the functional impairment of BETs is the main cause and prognostic determinant of common bacterial infections and subsequent multiple organ dysfunction syndrome (especially disseminated intravascular coagulation) remains to be determined. This evidence concerns the gene BRD4 and bacterial infectious disease.