NOS2 and infection: For example, pan-BETi protects against endotoxic shock, polymicrobial peritonitis, polymicrobial sepsis induced by cecal ligation and puncture,69 LPS-induced periodontitis,95 and vascular inflammation.13 The genetic inhibition of BRD4 decreases NOS2 expression and inflammation response in Listeria monocytogenes-induced macrophages in vitro.94 In vivo, mice with a myeloid lineage-specific deletion of Brd4 are more sensitive to group B Streptococcus-induced infection, but are resistant to LPS-induced endotoxic shock,97 indicating a different role of BRD4 in infection.