BRD4 and hereditary clear cell renal cell carcinoma: For instance, in renal cell carcinoma tissues and cells, the inhibition of BRD4 through genetic knockdown or JQ1 prevents proliferation and epithelial mesenchymal transition (EMT) by increasing RELA-mediated NLRP3 expression and subsequent pyroptosis.33 Collectively, the role of BETs in NLRP3 inflammasomes is cell type-specific, which depends on different transduction signals (Fig. 3).