Moreover, the activation of BET pathway, especially BRD2-mediated inflammatory response and pyroptosis, aggravates cerebral ischemia-induced brain injury and acute spinal cord injury.47,75,166 Thus it can be concluded that BET-mediated activation of inflammatory pathways is an important pathological event leading to neurological disorders, and the correlation of BETs with other neuroinflammation-associated refractory diseases, such as depression, autistic disorder, and epilepsy, can also be attempted. This evidence concerns the gene DNER and major depressive disorder.