BRD3 and viral infectious disease: Indeed, virus infection, such as through sendai virus, vesicular stomatitis virus, and herpes simplex virus, remarkably downregulate BRD3 expression in macrophages, thereby inhibiting the production of IFNB.50 As such, BET expression level is important for the establishment of antiviral immune homeostasis, and it may be useful for disease severity assessment and prognostic prediction of viral infection.