CMPK2 and systemic sclerosis: In addition to Parkinson’s disease, dysfunctional BETs are also associated with Alzheimer’s disease due to their role in maintaining chronic inflammation.165 BETs promote systemic sclerosis by decreasing the acetylation and expression of two IFN-dependent genes (MX1 and CMPK2) in monocytes,109 suggesting that BET-dependent IFN signaling is a therapeutic target for systemic sclerosis.