In addition to normal cells, BRD4 is highly expressed in different types of tumor cells (e.g., cells of renal cell carcinoma,33 malignant pleural mesothelioma,34 pancreatic ductal adenocarcinoma,35 melanoma,36 and primary human mucoepidermoid carcinoma37), and it can protect these tumor cells against immunogenic cell death, a type of regulated cell death that enhances tumor targeting immunity. Here, BRD4 is linked to hereditary clear cell renal cell carcinoma.