BRD2 and cancer: In addition, both BRD2 and BRD4 play key roles in the onset of cancer cachexia by increasing the transcription of catabolic genes regulated by the IL6-AMPK-FOXO3 pathway.174 However, little is known about how BETs cause the interaction between immune and metabolic dysfunction in the TME, and how they link the metabolic disturbance of immune cells to immune dysfunction.