BRD3 and cancer: For instance, BRD4 can bind to the promoters of ARGINASE1 and other IL4-driven macrophage genes such as IL6, RETNLB, and CHIA, which results in immunosuppression in the TME.146 BRD4, but not BRD2 or BRD3, promotes TME inflammation in triple-negative breast cancer through upregulating multiple genes involved in extracellular matrix regulation, such as COL1A2, COL3A1, COL5A2, and KRT19.147 Chronic inflammation can induce DNA damage and accelerate gene mutations, which contribute to the development and progression of cancer.