Our published work shows that the ERβ-selective agonist S-equol promotes human ERβ phosphorylation at Y36 in breast cancer cells.9 S-equol further enhanced TCR-activated ERβ tyrosine phosphorylation in anti-CD3/CD28-stimulated mouse EL4 lymphoma cells (figure 4A). The gene discussed is ESR2; the disease is breast carcinoma.