In concordance with more aggressive tumor growth in KI mice, immunophenotyping of tumor-infiltrating lymphocytes (TILs) indicates that abundance of total CD3+ immune cells, CD4+ T cells, CD8+ T cells and CD11c+ dendritic cells was substantially lower in tumors from KI hosts vs WT control (figure 1E–H, online supplemental figure S3A-F). This evidence concerns the gene CD4 and neoplasm.