Numerous clinical studies have also confirmed that the enrichment of CD8+ T cells indicates a good prognosis for patients with CRC and the potential of benefiting from ICIs treatment.36–39 Extraction of MSS CRC samples from TCGA database (mRNA expression data) also confirmed that high expression of PD-L1 predicted a better antitumor immune cell infiltration. Here, CD274 is linked to colorectal carcinoma.