CD274 and colorectal carcinoma: Consistent with our findings, other investigators have identified that miR-15b levels were significantly lower in the PD-L1-positive samples in malignant pleural mesothelioma.40 In addition, CAC and APCmin/+ murine models further confirmed that blocking miR-15b-5p promoted CRC tumorigenesis by inhibiting the recruitment of CD8+ T cells.