These seven cytokines including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), interleukin-17A (IL-17A), interleukin-21 (IL-21), and IFN-γ are well-known core proinflammatory cytokines or immunomodulatory cytokines in CRC.32 Only IL-17A and IFN-γ significantly downregulated the miR-15b-5p level (figure 4A). Here, IL21 is linked to colorectal carcinoma.