TARDBP and amyotrophic lateral sclerosis: Moreover, Nonaka et al. [34] found that sarkosyl-insoluble TDP-43 from ALS or FTLD brains could induce TDP-43 aggregation in SH-SY5Y cells, and these cells subsequently formed ubiquitinated, phosphorylated, insoluble cytoplasmic TDP-43 inclusions in a self-templating manner.