Until recently, Porta et al. [36] showed that intracerebral injection of pathological TDP-43 derived from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) brains led to the formation and trans-neuronal spreading of TDP-43 pathology in both CamKIIa-hTDP43NLSm and non-transgenic mice. This evidence concerns the gene TARDBP and frontotemporal dementia.